Free Practice Question of the Week [5]

Which of the following antidepressants has the highest potential to raise blood pressure at high doses?

a) Sertraline
b) Trazodone
c) Paroxetine
d) Duloxetine

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(D) is the answer.

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI), compared to the other options which are selective serotonin reuptake inhibitors (SSRI). Because duloxetine leads to increased levels of norepinephrine, it can potentially increase blood pressure at high doses.

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