PEBC: What You Need to Know: Anticholinergic Urinary Agents

PEBC What You Need to Know
Written By Alan Wong

Examples:

oxybutynin, tolterodine, fesoterodine, trospium, darifenacin, solifenacin

Mechanism:

Via anticholinergic action, increasing muscle tone at the bladder to inhibit voiding

Dosing:

oxybutynin, trospium, tolterodine: once to twice daily

other agents (and extended release versions): once daily

*trospium is on an empty stomach

Adverse Effects: (Anticholinergic toxicity)

blurred vision (pupil dilation)

dry mouth - use mouth moisturizers

confusion - caution in elderly

constipation

dizziness

drowsiness

tachycardia

adverse effects may be mitigated by choosing extended release versions or oxybutynin patch

Drug Interactions:

-CYP 3A4 inhibitors: caution with many of these agents

-CYP 2D6 inhibitors: caution with darifenacin and fesoterodine

-caution with other anticholinergic and CNS depressants due to additive effects


Alan Wong
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